Protein-Protein Interaction Antagonists as Novel Inhibitors of Non-Canonical Polyubiquitylation

Protein-Protein Interaction Antagonists as Novel Inhibitors of Non-Canonical Polyubiquitylation

BACKGROUND Several pathways that control cell survival under stress, namely RNF8-dependent DNA damage recognition and repair, PCNA-dependent DNA damage tolerance and activation of NF-kappaB by extrinsic signals, are regulated by the tagging of key proteins with lysine 63-based polyubiquitylated chains, catalyzed by the conserved ubiquitin conjugating heterodimeric enzyme Ubc13-Uev. METHODOLOG...

Small Molecules as Protein-Protein Interaction Inhibitors

Protein-protein interactions (PPIs) can be considered as a vast class of therapeutic targets. PPIs play critical roles in all biological functions and are often dysregulated in disease. Despite their functional role both inside and outside the cell, over the past decades PPIs have been neglected as undruggable targets. This was in part due to the fact that PPI interfaces are generally flat and ...

Novel Inhibitors of Protein-Protein Interaction for Prostate Cancer Therapy

Prediction of Protein Sub-Mitochondria Locations Using Protein Interaction Networks

Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...

small molecules as protein-proteininteraction inhibitors

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